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Existing evidence indicates that eating disorders can increase the risk of diabetes, obesity, hypertension, hypertriglyceridemia, headache, back pain, and other chronic metabolic diseases
Urine albumin was measured using a turbidimetric assay and urine creatinine by colorimetric assay (both Roche Cobas Chemistry Analyzer), and UACR was calculated at baseline, 24 weeks and 52 weeks
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Therefore, there is a huge demand for developing effective approaches to deliver therapeutic agents through the BBB to treat GBM and other primary brain tumors [27, 28] In this review, we have focused on the current challenges and prospects of overcoming the BBB challenge and reaching brain tumors, especially in the case of GBM and gliomas, using (i) clinically relevant drugs, (ii) different invasive and non-invasive methods, and (iii) organic/inorganic nanocarriers, viral-like particles (VLPs) and cell-based delivery systems to enhance the therapeutic efficacy against brain tumors
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